Repurposing an Ancient Drug in New Application

Abstract

Metformin is one of the most widely prescribed oral hypoglycemic agents from the biguanides group used in diabetes mellitus. Metformin pleiotropic effects have recently received increased attention because of its potential cytotoxic effects on a variety of cancers. Cancer is the uncontrolled growth and spread of abnormal cells. There is a growing body of evidence about a link between D.M and the risk of some types of cancer, mainly because diabetes is a state with increased oxidative stress and inflammation, all of which can, in turn, promote carcinogenesis

Aim of study to evaluate the effect of metformin (different doses and times) on inflammatory markers (IL-1β and TNF-α), and oxidative stress on diabetes models, with the major aim is to study the cytotoxic effect of metformin on the growth of cancer cell lines and possible mechanisms of cytotoxic impact.